Article
Autophagy Process in Parkinson's Disease Depends on Mutations in the GBA1 and LRRK2 Genes.
Biochemical genetics - 1 Apr 2026
Bezrukova A I, Basharova K S, Emelyanov A K, Rybakov A V, Miliukhina I V, Pchelina S N, Usenko T S
Abstract excerpt
Parkinson's disease (PD) is a common neurodegenerative disorder characterized by the loss of dopaminergic neurons and abnormal aggregation of the alpha-synuclein protein. Disruption of the autophagy-lysosomal pathway is closely associated with PD pathogenesis. Here, using western-blot analysis we assessed the level of autophagy-related proteins, including phosphorylated mTOR (p-mTOR), phosphorylated RPS6...
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