Article

The Nrf2-NLRP3-Caspase1 axis mediates the neuroprotective effects of Celastrol in Parkinson's disease

2020-08-07

Abstract excerpt

<title>Abstract</title> <p><bold>Background: </bold>Parkinson’s disease (PD) is characterized by the loss of dopaminergic neurons in the substantia nigra pars compacta (SNc), accompanied by chronic neuroinflammation, oxidative stress, and widespread accumulation of α-synuclein. Celastrol (Cel), a potent anti-inflammatory and anti-oxidative pentacyclic triterpene, has emerged as a neuroprotective agent. However, t...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work: f6c0c069-5e21-52c6-9e41-d18bfc2a36f6
DOI: 10.21203/rs.3.rs-50111/v1

Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest

The Nrf2-NLRP3-Caspase1 axis mediates the neuroprotective effects of Celastrol in Parkinson's diseaseDOI 10.21203/rs.3.rs-50111/v1Read

Targeting the Interplay Between Autophagy and the Nrf2 Pathway in Parkinson’s Disease with Potential Therapeutic ImplicationsSemantic proximity Read

A novel Long-noncoding RNA LncZFAS1 prevents MPP+-induced neuroinflammation through MIB1 activationSemantic proximity Read

Ellagic acid produces neuroprotection against LPS-induced dopamine neurotoxicity via the inhibition of microglial NLRP3 inflammasome activationSemantic proximity Read

Ellagic acid produces neuroprotection against LPS-induced dopamine neurotoxicity via the inhibition of microglial NLRP3 inflammasome activationSemantic proximity Read

Ellagic acid produces neuroprotection against LPS-induced dopamine neurotoxicity via the inhibition of microglial NLRP3 inflammasome activationSemantic proximity Read

A Novel Long-Noncoding RNA LncZFAS1 Prevents MPP+-Induced Neuroinflammation Through MIB1 ActivationSemantic proximity Read

Neuroprotective actions of a fatty acid nitroalkene in Parkinson’s disease.Semantic proximity Read

Ellagic acid protects from rotenone-induced dopaminergic neuronal damage via activation of Nrf2 signaling in astrogliaSemantic proximity Read

The potential applications of traditional Chinese medicine in Parkinson's disease: A new opportunitySemantic proximity Read

Activation of Nrf2 Neuroprotective Pathways for Treatment of Parkinson’s Disease: A State of Art ReviewSemantic proximity Read

Targeting Nrf2-Mediated Gene Transcription by Extremely Potent Synthetic Triterpenoids Attenuate Dopaminergic Neurotoxicity in the MPTP Mouse Model of Parkinson's DiseaseSemantic proximity Read

Activation of transcription factor Nrf2 to counteract mitochondrial dysfunction in Parkinson's diseaseSemantic proximity Read