MicroRNA-7 targets Nod-like receptor protein 3 inflammasome to modulate neuroinflammation in the pathogenesis of Parkinson’s disease

Abstract excerpt

BACKGROUND: α-Synuclein (α-Syn), a pathological hallmark of Parkinson's disease (PD), has been recognized to induce the production of interleukin-1β in a process that depends, at least in vitro, on nod-like receptor protein 3 (NLRP3) inflammasome in monocytes. However, the role of NLRP3 inflammasome activation in the onset of PD has not yet been fully established. RESULTS: In this study, we showed that NLRP3...

Topics

Share this publication in a Topic to start or enrich a Post.

• Share to Inflammasome and immune disorders
• Share to Neuroinflammation and Neurodegeneration Mechanisms
• Share to Parkinson's Disease Mechanisms and Treatments