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Article

Therapeutic potential of engineering the mitochondrial genome.

Biochimica et biophysica acta. Molecular basis of disease - 1 Oct 2023

Liu Mengmeng, Ji Wei, Zhao Xin, Liu Xiaoliang, Hu Ji-Fan, Cui Jiuwei

Abstract excerpt

Mitochondrial diseases are a group of clinical disorders caused by mutations in the genes encoded by either the nuclear or the mitochondrial genome involved in mitochondrial oxidative phosphorylation. Disorders become evident when mitochondrial dysfunction reaches a cell-specific threshold. Similarly, the severity of disorders is related to the degree of gene mutation. Clinical treatments for mitochondrial...

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PMID: 37429560
DOI: 10.1016/j.bbadis.2023.166804

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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