Article

Integrative profiling of early host chromatin accessibility responses in human neutrophils with sensitive pathogen detection

2020-04-30

Abstract excerpt

Sepsis is a leading cause of death globally where neutrophils respond to pathogens via tightly regulated antimicrobial effectors. Combining early neutrophilic responses and pathogen detection may reveal insights for disease recognition. We performed ATAC-seq of human neutrophils challenged with six toll-like receptor ligands and two organisms; and RNA-seq after Escherichia coli (EC) exposure for 1 and 4 hours alo...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work: 153f14a1-04e5-5960-b613-ef48d9560ac7
DOI: 10.1101/2020.04.28.066829

Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest

Integrative profiling of early host chromatin accessibility responses in human neutrophils with sensitive pathogen detectionDOI 10.1101/2020.04.28.066829Read

Cytokine-induced Chromatin Accessibility in Whole Blood Neutrophils Links to Sepsis Transcriptional StatesSemantic proximity Read

Chromatin Changes Associated with Neutrophil Extracellular Trap (NET) Formation in Whole Blood Reflect Complex Immune SignalingSemantic proximity Read

Upon microbial challenge human neutrophils undergo rapid changes in nuclear architecture to orchestrate an immediate inflammatory gene programSemantic proximity Read

ScRNA-Seq study of neutrophils reveals vast heterogeneity and breadth of inflammatory responses in severe COVID-19 patientsSemantic proximity Read

Human and murine neutrophils share core transcriptional programs in both homeostatic and inflamed contextsSemantic proximity Read

Profiling Transcription Initiation in Peripheral Leukocytes Reveals Severity-Associated Cis-Regulatory Elements in Critical COVID-19Semantic proximity Read

RNA Atlas of Human Bacterial Pathogens Uncovers Stress Dynamics Linked to InfectionSemantic proximity Read

Multi-Omics Profiling Reveals Phenotypic and Functional Heterogeneity of Neutrophils in COVID-19.Semantic proximity Read

An Immune Cell Atlas Reveals Dynamic COVID-19 Specific Neutrophil Programming Amenable to Dexamethasone TherapySemantic proximity Read

Netome: The Molecular Characterization of Neutrophil Extracellular Traps (NETs)Semantic proximity Read

Mapping disease regulatory circuits at cell-type resolution from single-cell multiomics dataSemantic proximity Read

A pan-immune panorama of bacterial pneumonia revealed by a large-scale single-cell transcriptome atlasSemantic proximity Read