Article

Identification of Aryl Hydrocarbon Receptor as a Barrier to HIV-1 Infection and Outgrowth in CD4 <sup>+</sup> T-Cells

2022-10-21

Abstract excerpt

<h4>ABSTRACT</h4> The Aryl hydrocarbon receptor (AhR) identifies “ non-pathogenic ” Th17-polarized CD4 + T-cells in autoimmune models. Thus, we explored whether AhR restricts HIV-1 in Th17-cells, consistent with its antiviral role in macrophages. AhR-specific CRISPR/Cas9-mediated knockout and pharmacological blockade decreased AhR target gene expression (CYP1A1/IL-22/IL-17A/IL-10/ ITGB7), while increasing HIV-1...

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Literature Corpus work: c5da7a5c-584b-5086-a9bf-6995797157bb
DOI: 10.1101/2022.10.17.512596

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