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A targeted CRISPR screen identifies ETS1 as a regulator of HIV-1 latency

8 Apr 2025

Abstract excerpt

Human Immunodeficiency virus (HIV) infection is regulated by a wide array of host cell factors that combine to influence viral transcription and latency. To understand the complex relationship between the host cell and HIV-1 latency, we performed a lentiviral CRISPR screen that targeted a set of host cell genes whose expression or activity correlates with HIV-1 expression. We further investigated one of the...

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PMID: 40198713
DOI: 10.1371/journal.ppat.1012467

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