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Potent and Targeted Activation of Latent HIV-1 Using the CRISPR/dCas9 Activator Complex

19 Nov 2015

Abstract excerpt

HIV-1 provirus integration results in a persistent latently infected reservoir that is recalcitrant to combined antiretroviral therapy (cART) with lifelong treatment being the only option. The "shock and kill" strategy aims to eradicate latent HIV by reactivating proviral gene expression in the context of cART treatment. Gene-specific transcriptional activation can be achieved using the RNA-guided CRISPR-Cas9...

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PMID: 26581162
DOI: 10.1038/mt.2015.202

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