Article

Generative inverse design of RNA structure and function with gRNAde

2025-12-01

Abstract excerpt

The design of RNA molecules with bespoke three-dimensional structures and functions is a central goal in synthetic biology and biotechnology. However, progress has been limited by the challenges of designing complex tertiary interactions such as pseudoknots, as well as engineering catalytic functions—problems that have remained largely intractable for automated methods. Here we present a high-throughput generative...

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Identifiers and source

Literature Corpus work: 93728158-e042-5e28-b9d4-b3e6a03a9961
DOI: 10.1101/2025.11.29.691298

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