Article
Enhancing luciferase activity and stability through generative modeling of natural enzyme sequences.
Proceedings of the National Academy of Sciences of the United States of America - 28 Nov 2023
Xie Wen Jun, Liu Dangliang, Wang Xiaoya, Zhang Aoxuan, Wei Qijia, Nandi Ashim, Dong Suwei, Warshel Arieh
Abstract excerpt
The availability of natural protein sequences synergized with generative AI provides new paradigms to engineer enzymes. Although active enzyme variants with numerous mutations have been designed using generative models, their performance often falls short of their wild type counterparts. Additionally, in practical applications, choosing fewer mutations that can rival the efficacy of extensive sequence alterations...
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