Article

Removal of Spo11 from meiotic DNA breaks <i>in vitro</i> but not <i>in vivo</i> by Tyrosyl DNA Phosphodiesterase 2

2019-01-23

Abstract excerpt

<h4>ABSTRACT</h4> Meiotic recombination events are initiated by DNA double-strand breaks (DSBs) created by the topoisomerase-like protein, Spo11. Similar to type-II topoisomerases, Spo11 becomes covalently linked to the 5′ ends generated on each side of the DSB. Whilst Spo11-oligos—the product of nucleolytic removal by Mre11—have been detected in a number of biological systems, the lifetime of the covalent Spo11-...

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Literature Corpus work: c5d0ebe2-aa1e-55c7-8613-dc470385966b
DOI: 10.1101/527333

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