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Article

Saccharomyces cerevisiae Mer2, Mei4 and Rec114 form a complex required for meiotic double-strand break formation.

Genetics - 1 Aug 2006

Li Jing, Hooker Gillian W, Roeder G Shirleen

Abstract excerpt

In budding yeast, at least 10 proteins are required for formation of the double-strand breaks (DSBs) that initiate meiotic recombination. Spo11 is the enzyme responsible for cleaving DNA and is found in a complex that also contains Ski8, Rec102, and Rec104. The Mre11/Rad50/Xrs2 complex is required for both DSB formation and DSB processing. In this article we investigate the functions of the remaining three...

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Identifiers

PMID: 16783010
DOI: 10.1534/genetics.106.058768
PMCID: PMC1569690

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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Saccharomyces cerevisiae Mer2, Mei4 and Rec114 form a complex required for meiotic double-strand break formation.PMID 16783010Read ↗

The multiple roles of the Mre11 complex for meiotic recombination.Semantic proximity Read ↗

Rec8p, a meiotic recombination and sister chromatid cohesion phosphoprotein of the Rad21p family conserved from fission yeast to humans.Semantic proximity Read ↗

Support for a meiotic recombination initiation complex: interactions among Rec102p, Rec104p, and Spo11p.Semantic proximity Read ↗

Genetic Interactions of Histone Modification Machinery Set1 and PAF1C with the Recombination Complex Rec114-Mer2-Mei4 in the Formation of Meiotic DNA Double-Strand Breaks.Semantic proximity Read ↗

The signal from the initiation of meiotic recombination to the first division of meiosis.Semantic proximity Read ↗

Ctp1CtIP and Rad32Mre11 nuclease activity are required for Rec12Spo11 removal, but Rec12Spo11 removal is dispensable for other MRN-dependent meiotic functions.Semantic proximity Read ↗

Rec8 phosphorylation by casein kinase 1 and Cdc7-Dbf4 kinase regulates cohesin cleavage by separase during meiosis.Semantic proximity Read ↗

Rec8 guides canonical Spo11 distribution along yeast meiotic chromosomes.Semantic proximity Read ↗

Functional interactions between SPO11 and REC102 during initiation of meiotic recombination in Saccharomyces cerevisiae.Semantic proximity Read ↗

Association of Mre11p with double-strand break sites during yeast meiosis.Semantic proximity Read ↗

Casein Kinase 1 and Phosphorylation of Cohesin Subunit Rec11 (SA3) Promote Meiotic Recombination through Linear Element Formation.Semantic proximity Read ↗

Positive regulation of meiotic DNA double-strand break formation by activation of the DNA damage checkpoint kinase Mec1(ATR).Semantic proximity Read ↗

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