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A DNA topoisomerase VI–like complex initiates meiotic recombination

25 Feb 2016

Abstract excerpt

The SPO11 protein catalyzes the formation of meiotic DNA double strand breaks (DSBs) and is homologous to the A subunit of an archaeal topoisomerase (topo VI). Topo VI are heterotetrameric enzymes comprising two A and two B subunits; however, no topo VIB involved in meiotic recombination had been identified. We characterized a structural homolog of the archaeal topo VIB subunit [meiotic topoisomerase VIB-like...

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PMID: 26917763
DOI: 10.1126/science.aad5196

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