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Article

Mre11 and Exo1 contribute to the initiation and processivity of resection at meiotic double-strand breaks made independently of Spo11.

DNA repair - 7 Feb 2011

Hodgson Adam, Terentyev Yaroslav, Johnson Rebecca A, Bishop-Bailey Anna, Angevin Thibaut, Croucher Adam, Goldman Alastair S H

Abstract excerpt

During meiosis DNA double-strand breaks (DSBs) are induced and repaired by homologous recombination to create gene conversion and crossover products. Mostly these DSBs are made by Spo11, which covalently binds to the DSB ends. More rarely in Saccharomyces cerevisiae, other meiotic DSBs are formed by self-homing endonucleases such as VDE, which is site specific and does not covalently bind to the DSB ends. We have...

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Source

Identifiers

PMID: 21146476
DOI: 10.1016/j.dnarep.2010.11.008

Genes

EXO1
MRE11

Variants

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

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Research trail→

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Mre11 and Exo1 contribute to the initiation and processivity of resection at meiotic double-strand breaks made independently of Spo11.PMID 21146476Read ↗

The multiple roles of the Mre11 complex for meiotic recombination.Semantic proximity Read ↗

Mapping yeast mitotic 5' resection at base resolution reveals the sequence and positional dependence of nucleases in vivo.Semantic proximity Read ↗

Temporally and biochemically distinct activities of Exo1 during meiosis: double-strand break resection and resolution of double Holliday junctions.Semantic proximity Read ↗

Meiotic DNA break resection and recombination rely on chromatin remodeler Fun30.Semantic proximity Read ↗

Physical interaction with Spo11 mediates the localisation of Mre11 to chromatin in meiosis and promotes its nuclease activity.Semantic proximity Read ↗

Overlapping functions of the Saccharomyces cerevisiae Mre11, Exo1 and Rad27 nucleases in DNA metabolism.Semantic proximity Read ↗

Association of Mre11p with double-strand break sites during yeast meiosis.Semantic proximity Read ↗

Ctp1CtIP and Rad32Mre11 nuclease activity are required for Rec12Spo11 removal, but Rec12Spo11 removal is dispensable for other MRN-dependent meiotic functions.Semantic proximity Read ↗

Ctp1-dependent clipping and resection of DNA double-strand breaks by Mre11 endonuclease complex are not genetically separable.Semantic proximity Read ↗

Exo1 roles for repair of DNA double-strand breaks and meiotic crossing over in Saccharomyces cerevisiae.Semantic proximity Read ↗

A pathway for error-free non-homologous end joining of resected meiotic double-strand breaks.Semantic proximity Read ↗

mre11S--a yeast mutation that blocks double-strand-break processing and permits nonhomologous synapsis in meiosis.Semantic proximity Read ↗

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