Mre11 and Exo1 contribute to the initiation and processivity of resection at meiotic double-strand breaks made independently of Spo11.

doi:10.1016/j.dnarep.2010.11.008

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Article

Mre11 and Exo1 contribute to the initiation and processivity of resection at meiotic double-strand breaks made independently of Spo11.

DNA repair - 7 Feb 2011

Hodgson Adam, Terentyev Yaroslav, Johnson Rebecca A, Bishop-Bailey Anna, Angevin Thibaut, Croucher Adam, Goldman Alastair S H

Abstract excerpt

During meiosis DNA double-strand breaks (DSBs) are induced and repaired by homologous recombination to create gene conversion and crossover products. Mostly these DSBs are made by Spo11, which covalently binds to the DSB ends. More rarely in Saccharomyces cerevisiae, other meiotic DSBs are formed by self-homing endonucleases such as VDE, which is site specific and does not covalently bind to the DSB ends. We have...

Topics

DNA Breaks, Double-Stranded
DNA Repair
DNA, Single-Stranded
Endodeoxyribonucleases
Exodeoxyribonucleases
Gene Conversion
Meiosis
Mutation
Proton-Translocating ATPases
Recombination, Genetic
Saccharomyces cerevisiae
Saccharomyces cerevisiae Proteins

Source

Open in PubMed

Identifiers

PMID: 21146476
DOI: 10.1016/j.dnarep.2010.11.008

Genes

EXO1
MRE11

Variants

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 31 Aug 2026.

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