Article

Detecting genome-wide directional effects of transcription factor binding on polygenic disease risk

2017-10-17

Abstract excerpt

Biological interpretation of GWAS data frequently involves analyzing unsigned genomic annotations comprising SNPs involved in a biological process and assessing enrichment for disease signal. However, it is often possible to generate signed annotations quantifying whether each SNP allele promotes or hinders a biological process, e.g., binding of a transcription factor (TF). Directional effects of such annotations...

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Literature Corpus work: c5bacda0-bda4-5ea5-b2ac-16e16747527e
DOI: 10.1101/204685

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