Article

Disruption of CPSF6 enhances cellular permissivity to HIV-1 infection through alternative polyadenylation

2024-12-04

Abstract excerpt

<title>Abstract</title> <p>Human immunodeficiency virus (HIV) relies upon a broad array of host factors in order to replicate and evade the host antiviral response<sup>1</sup>. Cleavage and polyadenylation specificity factor 6 (CPSF6) is one such host factor that is recruited by incoming HIV-1 cores to regulate trafficking<sup>2</sup>, nuclear import<sup>3-5</sup>, uncoating<sup>6</sup>, and integration site sele...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work: c585a00e-3af2-5a48-a096-431c43ac99b9
DOI: 10.21203/rs.3.rs-5099896/v1

Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest

Disruption of CPSF6 enhances cellular permissivity to HIV-1 infection through alternative polyadenylationDOI 10.21203/rs.3.rs-5099896/v1Read

HIV-1 Infection Regulates Gene Expression by Altering Alternative Polyadenylation Through CPSF6 and CPSF5 DelocalizationSemantic proximity Read

Capsid-CPSF6 Interaction Is Dispensable for HIV-1 Replication in Primary Cells but Is Selected during Virus Passage <i>In Vivo</i>Semantic proximity Read

Viral Hijacking of Host Polyadenylation Machinery to Regulate Post-Transcriptional Gene ExpressionSemantic proximity Read

A Carboxy-Terminally Truncated Human CPSF6 Lacking Residues Encoded by Exon 6 Inhibits HIV-1 cDNA Synthesis and Promotes Capsid DisassemblySemantic proximity Read

HIV-1 Capsid-Targeting Domain of Cleavage and Polyadenylation Specificity Factor 6Semantic proximity Read

YTHDC1 regulates distinct post-integration steps of HIV-1 replication and is important for viral infectivitySemantic proximity Read

The HIV-1 capsid-binding host factor CPSF6 is post-transcriptionally regulated by the cellular microRNA miR-125b.Semantic proximity Read

A critical role for alternative polyadenylation factor CPSF6 in targeting HIV-1 integration to transcriptionally active chromatin.Semantic proximity Read

Multi-Omics Single-Cell Analysis Reveals Key Regulators of HIV-1 Persistence and Aberrant Host Immune Responses in Early InfectionSemantic proximity Read

Truncated CPSF6 Forms Higher-Order Complexes That Bind and Disrupt HIV-1 Capsid.Semantic proximity Read

C19ORF66 is an Interferon-Stimulated Gene (ISG) which Inhibits Human Immunodeficiency Virus-1Semantic proximity Read

The sequestration of miR-642a-3p by a complex formed by HIV-1 Gag and human Dicer increases AFF4 expression and viral productionSemantic proximity Read