Article

The sequestration of miR-642a-3p by a complex formed by HIV-1 Gag and human Dicer increases AFF4 expression and viral production

2023-05-26

Abstract excerpt

<h4>ABSTRACT</h4> Micro (mi)RNAs are critical regulators of gene expression in human cells, the functions of which can be affected during viral replication. Here, we show that the human immunodeficiency virus type 1 (HIV-1) structural precursor Gag protein interacts with the miRNA processing enzyme Dicer. RNA immunoprecipitation and sequencing experiments show that Gag modifies the retention of a specific miRNA s...

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Literature Corpus work: 0fab7f45-a861-5f85-bbfb-ed736652ac2b
DOI: 10.1101/2023.05.24.542197

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The sequestration of miR-642a-3p by a complex formed by HIV-1 Gag and human Dicer increases AFF4 expression and viral productionDOI 10.1101/2023.05.24.542197Read

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