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Article

Truncated CPSF6 Forms Higher-Order Complexes That Bind and Disrupt HIV-1 Capsid.

Journal of virology - 1 Jul 2018

Ning Jiying, Zhong Zhou, Fischer Douglas K, Harris Gemma, Watkins Simon C, Ambrose Zandrea, Zhang Peijun

Abstract excerpt

Cleavage and polyadenylation specificity factor 6 (CPSF6) is a human protein that binds HIV-1 capsid and mediates nuclear transport and integration targeting of HIV-1 preintegration complexes. Truncation of the protein at its C-terminal nuclear-targeting arginine/serine-rich (RS) domain produces a protein, CPSF6-358, that potently inhibits HIV-1 infection by targeting the capsid and inhibiting nuclear entry. To...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 29643241
DOI: 10.1128/JVI.00368-18
PMCID: PMC6002704

Genes

CPSF6

Provenance

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