Article
The HIV-1 capsid-binding host factor CPSF6 is post-transcriptionally regulated by the cellular microRNA miR-125b.
The Journal of biological chemistry - 10 Apr 2020
Chaudhuri Evan, Dash Sabyasachi, Balasubramaniam Muthukumar, Padron Adrian, Holland Joseph, Sowd Gregory A, Villalta Fernando, Engelman Alan N, Pandhare Jui, Dash Chandravanu
Abstract excerpt
Cleavage and polyadenylation specificity factor 6 (CPSF6) is a cellular protein involved in mRNA processing. Emerging evidence suggests that CPSF6 also plays key roles in HIV-1 infection, specifically during nuclear import and integration targeting. However, the cellular and molecular mechanisms that regulate CPSF6 expression are largely unknown. In this study, we report a post-transcriptional mechanism that...
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