Article
A critical role for alternative polyadenylation factor CPSF6 in targeting HIV-1 integration to transcriptionally active chromatin.
Proceedings of the National Academy of Sciences of the United States of America - 23 Feb 2016
Sowd Gregory A, Serrao Erik, Wang Hao, Wang Weifeng, Fadel Hind J, Poeschla Eric M, Engelman Alan N
Abstract excerpt
Integration is vital to retroviral replication and influences the establishment of the latent HIV reservoir. HIV-1 integration favors active genes, which is in part determined by the interaction between integrase and lens epithelium-derived growth factor (LEDGF)/p75. Because gene targeting remains significantly enriched, relative to random in LEDGF/p75 deficient cells, other host factors likely contribute to...
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