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Article

HIV-1 Capsid-Targeting Domain of Cleavage and Polyadenylation Specificity Factor 6

2 Feb 2012

Abstract excerpt

The antiviral factor CPSF6-358 restricts human immunodeficiency virus type 1 (HIV-1) infection through an interaction with capsid (CA), preventing virus nuclear entry and integration. HIV-1 acquires resistance to CPSF6-358 through an N74D mutation of CA that impairs binding of the antiviral factor. Here we examined the determinants within CPSF6-358 that are necessary for CA-specific interaction. Residues 314 to...

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PMID: 22301135
DOI: 10.1128/jvi.06607-11

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