Article

The FANCM-RMI1/2 complex promotes genomic instability and PARP inhibitor sensitivity in BRCA2-deficicient cells

2026-01-15

Abstract excerpt

<h4>SUMMARY</h4> Cancer cells lacking BRCA1 or BRCA2 must adapt to survive and proliferate despite defective DNA repair and high genomic instability. Restoration of homologous recombination (HR) through loss of DNA end protection rescues growth defects and promotes PARP inhibitor (PARPi) resistance in BRCA1-deficient cells; however, the genetic basis of adaptation to BRCA2 loss remains largely unexplored. To deli...

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Literature Corpus work: 58abc7f1-ec02-5b63-b510-72e586e781aa
DOI: 10.64898/2026.01.15.699681

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