Article

Cruciform-forming AT/TA repeats are acted upon by structure selective endonucleases and Rad51 prior to repositioning to the nuclear periphery for repair

2026-01-22

Abstract excerpt

Structure-forming DNA repeats can pose a barrier to DNA replication and repair, creating chromosomal fragile sites. An AT/TA DNA repeat, derived from the Flex1 region of human common fragile site FRA16D, can form hairpin and cruciform structures which interfere with DNA replication. When inserted into the S. cerevisiae genome, the Flex1(AT) 34 repeat stimulates chromosome deletions in a manner dependent on the M...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work: b65a0a71-492e-5d44-82b9-545aca4a91ab
DOI: 10.64898/2026.01.20.700634

Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest

Cruciform-forming AT/TA repeats are acted upon by structure selective endonucleases and Rad51 prior to repositioning to the nuclear periphery for repairDOI 10.64898/2026.01.20.700634Read

Structure-forming CAG/CTG repeats interfere with gap repair to cause repeat expansions and chromosome breaks.Semantic proximity Read

Linking Dynamic DNA Secondary Structures to Genome InstabilitySemantic proximity Read

Pathogenic CANVAS (AAGGG) <sub>n</sub> repeats stall DNA replication due to the formation of alternative DNA structuresSemantic proximity Read

DNA Instability at Chromosomal Fragile Sites in CancerSemantic proximity Read

Mutations in yeast replication proteins that increase CAG/CTG expansions also increase repeat fragility.Semantic proximity Read

Defective BRCA1-mediated DNA end resection drives tandem duplication formation and <i>FANCM</i> synthetic lethalitySemantic proximity Read

Chromosome fragility at GAA tracts in yeast depends on repeat orientation and requires mismatch repair.Semantic proximity Read

POLQ mediates replication-stress induced structural variant formation throughout common fragile sites during mitosisSemantic proximity Read

Human CST Facilitates Genome-wide RAD51 Recruitment to GC-Rich Repetitive Sequences in Response to Replication StressSemantic proximity Read

Molecular basis for expression of common and rare fragile sites.Semantic proximity Read

FANCM suppresses DNA replication stress at ALT telomeres by disrupting TERRA R-loops.Semantic proximity Read

Postreplication repair inhibits CAG.CTG repeat expansions in Saccharomyces cerevisiae.Semantic proximity Read