Back to search

Article

Validation of tissue-specific RNAi systems in <i>C. elegans</i> reveals a converging role for polyubiquitin UBQ-1/UBC in vitellogenin metabolism and lifespan

2026-02-23

Abstract excerpt

<h4>ABSTRACT</h4> Numerous studies in C. elegans have taken advantage of gene silencing RNAi libraries and tissue-specific RNAi systems to temporally and spatially understand gene function. Tissue-specific RNAi strains were created via tissue-specific functional expression of a key gene in the RNAi system in a presumably RNAi insensitive correspondingly mutated background. Here, we tested the level of RNAi insen...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work
c56d00d0-d84e-5e85-b340-b22e40e89853
DOI
10.64898/2026.02.21.707171
Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest
Interactive article relationship graphSelect a related publication card to move it into the centre and load its closest explainable connections. Solid lines are source-backed structured connections. Dashed lines are semantic discovery signals and are not scientific evidence.
Validation of tissue-specific RNAi systems in <i>C. elegans</i> reveals a converging role for polyubiquitin UBQ-1/UBC in vitellogenin metabolism and lifespanDOI 10.64898/2026.02.21.707171
Construction of a germline-specific RNAi tool in <i>C. elegans</i>Semantic proximity
E1 ubiquitin-activating enzyme UBA-1 plays multiple roles throughout C. elegans development.Semantic proximity
Tissue- and sex-specific small RNAomes reveal sex differences in response to the environmentSemantic proximity
Identification of Caenorhabditis elegans genes regulating longevity using enhanced RNAi-sensitive strains.Semantic proximity
C. elegans rrf-1 mutations maintain RNAi efficiency in the soma in addition to the germline.Semantic proximity
RNA interference in ageing research--a mini-review.Semantic proximity
Genome-wide temporal gene expression reveals a post-reproductive shift in the nematode <i>C. briggsae</i>Semantic proximity
New strains for tissue-specific RNAi studies in <i>Caenorhabditis elegans</i>Semantic proximity
Diversification of small RNA pathways underlies germline RNAi incompetence in wild <i>C. elegans</i> strainsSemantic proximity
A screenable in vivo assay to study proteostasis networks in Caenorhabditis elegans.Semantic proximity
Immunohistochemical analysis reveals variations in proteasome tissue expression in C. elegans.Semantic proximity
Genetics of lifespan in C. elegans: molecular diversity, physiological complexity, mechanistic simplicity.Semantic proximity
Select a neighboring publication to make it the new centre.