Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

C. elegans rrf-1 mutations maintain RNAi efficiency in the soma in addition to the germline.

PloS one - 1 Jan 2012

Kumsta Caroline, Hansen Malene

Abstract excerpt

Gene inactivation through RNA interference (RNAi) has proven to be a valuable tool for studying gene function in C. elegans. When combined with tissue-specific gene inactivation methods, RNAi has the potential to shed light on the function of a gene in distinct tissues. In this study we characterized C. elegans rrf-1 mutants to determine their ability to process RNAi in various tissues. These mutants have been...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Caenorhabditis elegans Proteins
Share to Forkhead Transcription Factors
Share to Intestinal Mucosa

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Organ Specificity

Share to RNA-Dependent RNA Polymerase

Share to Spermatozoa

Share to Superoxide Dismutase

Source

Open in PubMed Open full text

Identifiers

PMID: 22574120
DOI: 10.1371/journal.pone.0035428
PMCID: PMC3344830

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

C. elegans rrf-1 mutations maintain RNAi efficiency in the soma in addition to the germline.PMID 22574120Read ↗

Construction of a germline-specific RNAi tool in <i>C. elegans</i>Semantic proximity Read ↗

Establishment of a tissue-specific RNAi system in C. elegans.Semantic proximity Read ↗

Tissue specificity of Caenorhabditis elegans enhanced RNA interference mutants.Semantic proximity Read ↗

Gene activities that mediate increased life span of C. elegans insulin-like signaling mutants.Semantic proximity Read ↗

Validation of tissue-specific RNAi systems in <i>C. elegans</i> reveals a converging role for polyubiquitin UBQ-1/UBC in vitellogenin metabolism and lifespanSemantic proximity Read ↗

Intestine-specific removal of DAF-2 nearly doubles lifespan in Caenorhabditis elegans with little fitness cost.Semantic proximity Read ↗

New strains for tissue-specific RNAi studies in <i>Caenorhabditis elegans</i>Semantic proximity Read ↗

Germ-cell loss extends C. elegans life span through regulation of DAF-16 by kri-1 and lipophilic-hormone signaling.Semantic proximity Read ↗

A conserved siRNA-degrading RNase negatively regulates RNA interference in C. elegans.Semantic proximity Read ↗

Tissue- and sex-specific small RNAomes reveal sex differences in response to the environmentSemantic proximity Read ↗

Identification of Caenorhabditis elegans genes regulating longevity using enhanced RNAi-sensitive strains.Semantic proximity Read ↗

lin-35/Rb and xnp-1/ATR-X function redundantly to control somatic gonad development in C. elegans.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.