Article

Age-linked suppression of lipoxin A4 mediates cognitive deficits in mice and humans

2021-11-13

Abstract excerpt

Age increases the risk for cognitive impairment and is the single major risk factor for Alzheimer's disease (AD), the most prevalent form of dementia in the elderly. The pathophysiological processes triggered by aging that render the brain vulnerable to dementia involve, at least in part, changes in inflammatory mediators. Here we show that lipoxin A4 (LXA4), a lipid mediator of inflammation resolution known to st...

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Literature Corpus work: c56b60db-a6f3-543d-82ec-ed7bc7315163
DOI: 10.1101/2021.11.12.468379

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