Back to search

Article

ADMA metabolism and chronic hypoxia-induced pulmonary hypertenstion

2015-01-01

Abstract excerpt

Rationale: Elevated asymmetric dimethylarginine (ADMA) levels contribute to the pathogenesis of hypoxia-induced pulmonary hypertension. Chronic hypoxia decreases the activity of the enzymes metabolising ADMA, dimethylarginine dimethylaminohydrolases (DDAH1 and DDAH2) but the mechanisms responsible are not understood. Objective: To elucidate the physiological significance and the mechanism of hypoxia-induced downre...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work
c5590581-b151-5750-ae70-7b340565b982
DOI
10.25560/24911
Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest
Interactive article relationship graphSelect a related publication card to move it into the centre and load its closest explainable connections. Solid lines are source-backed structured connections. Dashed lines are semantic discovery signals and are not scientific evidence.
ADMA metabolism and chronic hypoxia-induced pulmonary hypertenstionDOI 10.25560/24911
The impact of methylarginine metabolism on disease progression in idiopathic pulmonary fibrosisSemantic proximity
The role of asymmetric dimethylarginine in murine pregnancy and its link to pregnancy-induced hypertensionSemantic proximity
Dimethylarginine dimethylaminohydrolase activity modulates ADMA levels, VEGF expression, and cell phenotype.Semantic proximity
A single nucleotide polymorphism in the dimethylarginine dimethylaminohydrolase gene is associated with lower risk of pulmonary hypertension in bronchopulmonary dysplasia.Semantic proximity
Dimethylarginine dimethylaminohydrolase-1 is the critical enzyme for degrading the cardiovascular risk factor asymmetrical dimethylarginine.Semantic proximity
The role of DDAH and ADMA in kidney diseaseSemantic proximity
Dimethylarginine Dimethylaminohydrolase 1 Polymorphisms and Venous Intimal Hyperplasia in Hemodialysis Patients.Semantic proximity
Genome-wide association study of L-arginine and dimethylarginines reveals novel metabolic pathway for symmetric dimethylarginine.Semantic proximity
DDAH gene and cardiovascular risk.Semantic proximity
A novel loss-of-function DDAH1 promoter polymorphism is associated with increased susceptibility to thrombosis stroke and coronary heart disease.Semantic proximity
The role of endogenous inhibitors of nitric oxide on glucose homeostasisSemantic proximity
Sequence variation in DDAH1 and DDAH2 genes is strongly and additively associated with serum ADMA concentrations in individuals with type 2 diabetes.Semantic proximity
Select a neighboring publication to make it the new centre.