Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Dimethylarginine Dimethylaminohydrolase 1 Polymorphisms and Venous Intimal Hyperplasia in Hemodialysis Patients.

American journal of nephrology - 1 Jan 2019

Wu Chih-Cheng, Hsieh Mu-Yang, Lee Chih-Kuo, Chuang Shao-Yuan, Chung Ming-Yi, Lin Chih-Ching

Abstract excerpt

BACKGROUND: After angioplasty, veins are more prone to intimal hyperplasia than arteries. Veins tend to produce less nitric oxide (NO), which could lead to endothelial dysfunction. Asymmetric dimethylarginine (ADMA) is an endogenous inhibitor of NO synthase and contributes to cardiovascular disease. In humans, dimethylarginine dimethylaminohydrolase 1 (DDAH1) is the major enzyme for ADMA degradation. In this...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Amidohydrolases
Share to Arginine

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Follow-Up Studies

Share to Hyperplasia

Share to Kidney Failure, Chronic

Share to Renal Dialysis

Share to Tunica Intima

Source

Identifiers

PMID: 31639806
DOI: 10.1159/000503949

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Dimethylarginine Dimethylaminohydrolase 1 Polymorphisms and Venous Intimal Hyperplasia in Hemodialysis Patients.PMID 31639806Read ↗

Genetic variation in the dimethylarginine dimethylaminohydrolase 1 gene (DDAH1) is related to asymmetric dimethylarginine (ADMA) levels, but not to endothelium-dependent vasodilation.Semantic proximity Read ↗

Distribution of dimethylarginine-dimethylaminohydrolase-II (DDAH2) gene polymorphism in hemodialysis patients.Semantic proximity Read ↗

Association of Genetic Polymorphisms of Renin-Angiotensin-Aldosterone System-Related Genes with Arterio-Venous Fistula Malfunction in Hemodialysis Patients.Semantic proximity Read ↗

Genetic causation of neointimal hyperplasia in hemodialysis vascular access dysfunction.Semantic proximity Read ↗

DDAH gene and cardiovascular risk.Semantic proximity Read ↗

Genome-wide association study of L-arginine and dimethylarginines reveals novel metabolic pathway for symmetric dimethylarginine.Semantic proximity Read ↗

Sequence variation in DDAH1 and DDAH2 genes is strongly and additively associated with serum ADMA concentrations in individuals with type 2 diabetes.Semantic proximity Read ↗

A novel loss-of-function DDAH1 promoter polymorphism is associated with increased susceptibility to thrombosis stroke and coronary heart disease.Semantic proximity Read ↗

ADMA metabolism and chronic hypoxia-induced pulmonary hypertenstionSemantic proximity Read ↗

Apolipoprotein E polymorphism modulation of asymmetric dimethylarginine in hypertensive patients is determined by renal function.Semantic proximity Read ↗

Asymmetric dimethylarginine levels are associated with augmentation index across naïve untreated patients with different hypertension phenotypesSemantic proximity Read ↗

A functional variant of the dimethylarginine dimethylaminohydrolase-2 gene is associated with insulin sensitivity.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.