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Article

A novel loss-of-function DDAH1 promoter polymorphism is associated with increased susceptibility to thrombosis stroke and coronary heart disease.

Circulation research - 2 Apr 2010

Ding Hu, Wu Bin, Wang Hu, Lu Zhilan, Yan Jiangtao, Wang Xiaojing, Shaffer John R, Hui Rutai, Wang Dao Wen

Abstract excerpt

RATIONALE: Asymmetrical dimethylarginine (ADMA), an endogenous arginine analogue, inhibits nitric oxide synthases and plays an important role in endothelial dysfunction. OBJECTIVE: In the present study, we tested whether a novel genetic variant in dimethylarginine dimethylaminohydrolase 1 (DDAH1), an important ADMA hydrolyzing gene, was associated with stroke and coronary heart disease (CHD) susceptibility in the...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

Identifiers

PMID: 20167924
DOI: 10.1161/CIRCRESAHA.109.215616

Genes

DDAH1

Provenance

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A novel loss-of-function DDAH1 promoter polymorphism is associated with increased susceptibility to thrombosis stroke and coronary heart disease.PMID 20167924Read ↗

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