Article

Promoter hijacking by primate LINC00473 disrupts an ancestral CREB-PDE10A feedback loop

2025-10-04

Abstract excerpt

<h4>ABSTRACT</h4> Thousands of human long noncoding RNAs (lncRNAs) evolved in primates, although much remains unknown about how these lncRNAs shaped human gene regulatory networks. The primate-specific lncRNA gene LINC00473 has a CREB-inducible promoter that is conserved beyond primates and the gene is located upstream of PDE10A, which encodes an inhibitor of CREB. To gain insight into the regulatory consequence...

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Literature Corpus work: c556cd98-57c5-5599-9abd-435942e92682
DOI: 10.1101/2025.10.02.680088

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