Computational prediction and CRISPR-Cas12a knockout and rescue assays identify many functionally conserved lncRNAs from zebrafish to human

Abstract excerpt

<title>Abstract</title> <p>Advances in RNA-seq studies have enabled transcriptome-scale annotation of long noncoding RNAs (lncRNAs) across vertebrates, with many of them having been implicated as regulators in diverse cellular processes^1–3. However, our understanding of lncRNA function has long been hindered by the lack of methods to assess lncRNA evolution across species^4–6. Here, we develo...

Topics

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• Age Factors
• Gene Expression Regulation, Developmental
• Genetic Variation
• High-Throughput Nucleotide Sequencing
• Phenotype
• RNA, Long Noncoding
• Transcriptome
• Zebrafish

Identifiers and source

Literature Corpus work

6a4218be-1f6f-5b28-ab76-3ee2dd90b341

DOI

10.21203/rs.3.rs-1920866/v1