Article

Human-specific lncRNAs contributed critically to human evolution by distinctly regulating gene expression

2023-06-01

Abstract excerpt

<h4>ABSTRACT</h4> What genes and regulatory sequences critically differentiate modern humans from apes and archaic humans, which share highly similar genomes but show distinct phenotypes, has puzzled researchers for decades. Previous studies examined species-specific protein-coding genes and related regulatory sequences, revealing that birth, loss, and changes in these genes and sequences can drive speciation and...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work: dc6ea61d-f1f9-5250-83ed-24936300d972
DOI: 10.1101/2023.05.31.543169

Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest

Human-specific lncRNAs contributed critically to human evolution by distinctly regulating gene expressionDOI 10.1101/2023.05.31.543169Read

Analysis of genomic loci harboring 59,732 human-specific regulatory sequences reveals unique to human regulatory patterns associated with brain developmentSemantic proximity Read

Long-range regulatory effects of Neandertal DNA in modern humansSemantic proximity Read

Mechanistically Distinct Pathways of Divergent Regulatory DNA Creation Contribute to Evolution of Human-Specific Genomic Regulatory Networks Driving Phenotypic Divergence of Homo sapiens.Semantic proximity Read

The cis-regulatory effects of modern human-specific variants.Semantic proximity Read

A Catalogue of 59,732 Human-Specific Regulatory Sequences Reveals Unique-to-Human Regulatory Patterns Associated with Virus-Interacting Proteins, Pluripotency, and Brain Development.Semantic proximity Read

The <i>cis</i> -regulatory effects of modern human-specific variantsSemantic proximity Read

Human gene regulatory evolution is driven by the divergence of regulatory element function in both <i>cis</i> and <i>trans</i>Semantic proximity Read

Long-range regulatory effects of Neandertal DNA in modern humans.Semantic proximity Read

Highly conserved sequence-specific DNA binding networks of 716 transcription factors associated with continuing divergent genomic evolution of human and chimpanzee brain development.Semantic proximity Read

Emerging Roles of Long Non-Coding RNAs as Drivers of Brain EvolutionSemantic proximity Read

Extensive evolutionary changes in regulatory element activity during human origins are associated with altered gene expression and positive selection.Semantic proximity Read

Intrinsically linked lineage specificity of transposable elements, lncRNA genes, and transcriptional regulationSemantic proximity Read