Article

Therapeutic Effect of Dual CAR-T Targeting PDL1 and MUC16 Antigens on Ovarian Cancer Cells in Mice

2020-07-16

Abstract excerpt

<h4>Background: </h4> More favorable treatment against epithelial ovarian cancer (EOC) is urgently needed because of its insidious nature at an early stage and a low rate of five-year survival. The current primary treatment, extensive surgery combined with chemotherapy, exhibits limited benefits for improving prognosis. Chimeric antigen receptor T (CAR-T) cell technology as novel immunotherapy has made breakthroug...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work: c50509b1-b4b1-5c16-be3c-708b25adaa46
DOI: 10.21203/rs.3.rs-26150/v3

Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest

Therapeutic Effect of Dual CAR-T Targeting PDL1 and MUC16 Antigens on Ovarian Cancer Cells in MiceDOI 10.21203/rs.3.rs-26150/v3Read

Immunotherapeutic Approaches in Ovarian CancerSemantic proximity Read

PD-L1 chimeric costimulatory receptor improves the efficacy of CAR-T cells for PD-L1-positive solid tumors and reduces toxicity in vivoSemantic proximity Read

Ligand-based adoptive T cell targeting CA125 in ovarian cancerSemantic proximity Read

Immunotherapy for ovarian cancer is improved by tumor-targeted delivery of a neoantigen surrogateSemantic proximity Read

Multifaceted therapeutic targeting of ovarian peritoneal carcinomatosis through virus-induced immunomodulation.Semantic proximity Read

Dendritic Cells Immunotherapy of Ovarian Cancer: Overview of Our AchievementsSemantic proximity Read

Tumor-associated macrophages mediate immune suppression by secreting PD-L1+ exosomes in epithelial ovarian cancerSemantic proximity Read

Insilico Identification of MHC displayed Tumor Associated Peptides in Ovarian Cancer for Multi-Epitope Vaccine ConstructSemantic proximity Read

HO-3867 mediated modulation of Extracellular vesicles and Tumor microenvironment: A novel immunotherapeutic strategy for ovarian cancerSemantic proximity Read

Intraperitoneal administration of carcinoembryonic antigen-directed CAR-T cells is a robust delivery route for effective treatment of peritoneal carcinomatosis from colorectal cancerSemantic proximity Read

Nanoparticle-mediated delivery of PD-L1 inhibitor enhances γδ T cell immunotherapy against metastatic ovarian cancer cellsSemantic proximity Read

TRAIL-R1-targeted chimeric antigen receptor T cells exhibit dual antitumor effectsSemantic proximity Read