Article

PD-L1 chimeric costimulatory receptor improves the efficacy of CAR-T cells for PD-L1-positive solid tumors and reduces toxicity in vivo

2020-10-22

Abstract excerpt

<h4>Background: </h4> On-target off-tumor toxicity impedes the clinical application of chimeric antigen receptor-modified T cells (CAR-T cells) in the treatment of solid tumors. Previous reports proved that the combinatorial antigen recognition strategy could improve the safety profile of CAR-T cells by targeting two different tumor-associated antigens (TAAs), one as a CAR-T targeted antigen and the other as a chi...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work: 805204e5-6344-510a-9c9d-6e004247de8a
DOI: 10.21203/rs.3.rs-65575/v2

Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest

PD-L1 chimeric costimulatory receptor improves the efficacy of CAR-T cells for PD-L1-positive solid tumors and reduces toxicity in vivoDOI 10.21203/rs.3.rs-65575/v2Read

CAR‐T‐cell products in solid tumors: Progress, challenges, and strategiesSemantic proximity Read

From molecular design to clinical translation: dual-targeted CAR-T strategies in cancer immunotherapySemantic proximity Read

TRAIL-R1-targeted chimeric antigen receptor T cells exhibit dual antitumor effectsSemantic proximity Read

PD-1 disrupted CAR-T cells in the treatment of solid tumors: Promises and challengesSemantic proximity Read

Targeting PD-L1 in solid cancer with myeloid cells expressing a CAR-like immune receptorSemantic proximity Read

Balancing activation and costimulation of CAR tunes signaling dynamics and enhances therapeutic potencySemantic proximity Read

Research progress on the intrinsic non‑immune function of PD‑L1 in tumors (Review)Semantic proximity Read

A PD-L1-targeting chimeric switch receptor enhances efficacy of CAR-T cell for pleural and peritoneal metastasisSemantic proximity Read

CAR-NK cells with dual targeting of PD-L1 and MICA/B in human lung cancer H1299 cell tumor modelSemantic proximity Read

Chimeric antigen receptor-modified T cells strike backSemantic proximity Read

Single-cell transcriptome analysis of the immunosuppressive effect of differential expression of tumor PD-L1 on responding TCR-T cellsSemantic proximity Read

Chimeric Antigen Receptors: A Paradigm Shift in ImmunotherapySemantic proximity Read