Article

TRAIL-R1-targeted chimeric antigen receptor T cells exhibit dual antitumor effects

2021-05-24

Abstract excerpt

Tumor necrosis factor-related apoptosis-inducing ligand receptor 1 (TRAIL-R1) has limited expression in normal tissues but highly expression in a broad range of tumors, making it an attractive target for cancer immunotherapy. We have previously prepared a fully human monoclonal antibody targeting TRAIL-R1 (TR1419), which can specifically induce apoptosis in antigen-positive tumor cells. Here, we prepared the TR141...

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Literature Corpus work: 706f3ba7-5493-5740-ba0f-c27b73283e28
DOI: 10.22541/au.162187087.70131237/v1

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