Article

Immunotherapy for ovarian cancer is improved by tumor-targeted delivery of a neoantigen surrogate

2023-10-12

Abstract excerpt

Ovarian cancer is known for its poor neoantigen expression and strong immunosuppression. Here, we utilized an attenuated non-pathogenic bacterium Listeria monocytogenes to deliver a highly immunogenic Tetanus Toxoid protein (Listeria-TT), as a neoantigen surrogate, into tumor cells through infection in a metastatic mouse ovarian cancer model (Id8p53-/-Luc). Gemcitabine (GEM) was added to reduce immune suppression...

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Literature Corpus work: 6c021ef5-ed8e-57c7-97d0-4ce4b8b82552
DOI: 10.1101/2023.10.11.561944

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