Article

Nanoparticle-mediated delivery of PD-L1 inhibitor enhances γδ T cell immunotherapy against metastatic ovarian cancer cells

2026-06-09

Abstract excerpt

<h4>Introduction</h4> Immune checkpoint inhibitors (ICIs) have only shown limited efficacy for patients with ovarian cancer (OC), partly due to the immune suppressive tumour microenvironment (TME) and platelet cloaking of the cancer cells. We tested a nanomedicine strategy to enhance γδ T cell immunotherapy by conjugating the PD-L1 inhibitor (BMS202) to nanodiamonds (NDs). <h4>Methods</h4> Patient-derived ascite...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work: a7357f7f-8232-5469-a223-33582d7df771
DOI: 10.64898/2026.06.04.730154

Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest

Nanoparticle-mediated delivery of PD-L1 inhibitor enhances γδ T cell immunotherapy against metastatic ovarian cancer cellsDOI 10.64898/2026.06.04.730154Read

HO-3867 mediated modulation of Extracellular vesicles and Tumor microenvironment: A novel immunotherapeutic strategy for ovarian cancerSemantic proximity Read

Immunotherapy for ovarian cancer is improved by tumor-targeted delivery of a neoantigen surrogateSemantic proximity Read

Ovarian cancer-on-chip for patient-specific profiling of treatment responses to sequential chemotherapy and PD-L1 blockadeSemantic proximity Read

Exploring the therapeutic use and outcome of antibody-drug conjugates in ovarian cancer treatmentSemantic proximity Read

Enhancing Patient Lymphocyte Response to Peritoneal Malignancies Using a Personalized Immunocompetent Microfluidic Co-Culture PlatformSemantic proximity Read

Ovarian Cancer in the Era of Immune Checkpoint Inhibitors: State of the Art and Future Perspectives.Semantic proximity Read

Neutralizing PD-L1 and PD-L2 Enhances the Efficacy of Immune Checkpoint Inhibitors in Ovarian CancerSemantic proximity Read

Malignant ascites enhance γδ T cell cytotoxicity towards ovarian cancer via modulating chemokines secretion from the cancer cells that recruits γδ T cellsSemantic proximity Read

Cell-derived Nanoparticles Provide a Robust Platform to Manufacture Therapeutic T cells.Semantic proximity Read

First-in-human phase I/II, open-label study of mRNA-2416 alone or combined with durvalumab in patients with advanced solid tumors and ovarian cancerSemantic proximity Read

Local Delivery of Accutox® Synergises With Immune-checkpoint Inhibitors at Disrupting Tumor GrowthSemantic proximity Read

PD-1 immune checkpoint blockade enhances FLOT chemotherapy toxicity in oesophageal adenocarcinoma cells via immune-independent mechanismsSemantic proximity Read