Article

Efficiency of protein synthesis inhibition depends on tRNA and codon compositions

2019-03-28

Abstract excerpt

Regulation and maintenance of protein synthesis are vital to all organisms and are thus key targets of attack and defense at the cellular level. Here, we mathematically analyze protein synthesis for its sensitivity to the inhibition of elongation factor EF-Tu and/or ribosomes in dependence of the system’s tRNA and codon compositions. We find that protein synthesis reacts ultrasensitively to a decrease in the elong...

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Literature Corpus work: c4ff6deb-bbba-5aba-ad51-8f587514765e
DOI: 10.1101/592204

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