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Isoleucine-to-valine substitutions support cellular physiology during isoleucine deprivation

9 Dec 2024

Abstract excerpt

Aminoacyl-tRNA synthetases (ARSs) couple tRNAs with their corresponding amino acids. While ARSs can bind structurally similar amino acids, extreme specificity is ensured by subsequent editing activity. Yet, we found that upon isoleucine (I) restriction, healthy fibroblasts consistently incorporated valine (V) into proteins at isoleucine codons, resulting from misacylation of tRNAIle with valine by wildtype IARS1....

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PMID: 39657787
DOI: 10.1093/nar/gkae1184

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