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Patient-Derived Air-Liquid Interface Forebrain Organoids Reveal Functional Synaptic Deficits in Schizophrenia

2026-06-03

Abstract excerpt

Schizophrenia (SCZ) is a severe and debilitating neurodevelopmental disorder with lifelong impact on everyday life. Disruptions in synapse functions play a key role in its complex and poorly understood etiological and pathological mechanisms. Here, we investigated both the molecular composition and the spontaneous and stimulated functional properties of synapses in neural organoids from SCZ individuals. Air-liquid...

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Literature Corpus work
9b7d080e-a226-5852-b4f5-06c09b615f4c
DOI
10.64898/2026.06.01.729183
Open publication

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Patient-Derived Air-Liquid Interface Forebrain Organoids Reveal Functional Synaptic Deficits in SchizophreniaDOI 10.64898/2026.06.01.729183
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