Article
Phenotypic differences in hiPSC NPCs derived from patients with schizophrenia.
Molecular psychiatry - 1 Mar 2015
Brennand K, Savas J N, Kim Y, Tran N, Simone A, Hashimoto-Torii K, Beaumont K G, Kim H J, Topol A, Ladran I, Abdelrahim M, Matikainen-Ankney B, Chao S-h, Mrksich M, Rakic P, Fang G, Zhang B, Yates J R, Gage F H
Abstract excerpt
Consistent with recent reports indicating that neurons differentiated in vitro from human-induced pluripotent stem cells (hiPSCs) are immature relative to those in the human brain, gene expression comparisons of our hiPSC-derived neurons to the Allen BrainSpan Atlas indicate that they most resemble fetal brain tissue. This finding suggests that, rather than modeling the late features of schizophrenia (SZ),...
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