Article

Variable Mutations at the p53-R273 Oncogenic Hotspot Position Leads to Altered Properties

2019-06-26

Abstract excerpt

Mutations in p53 protein, especially in the DNA binding domain is one of the major hallmarks of cancer. The R273 position is a DNA contact position and has several oncogenic variants. Surprisingly, cancer patients carrying different mutant-variants of R273 in p53 have different survival rates indicating that the DNA contact inhibition may not be the sole reason for reduced survival with R273 variants. Here, we pro...

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Literature Corpus work: c4f1a015-cfdf-5d76-a24a-6d535041e5f7
DOI: 10.1101/684407

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