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Structural and functional implications of p53 missense cancer mutations

26 Jun 2009

Abstract excerpt

Most human cancers contain mutations in the transcription factor p53 and majority of these are missense and located in the DNA binding core domain. In this study, the stabilities of all core domain missense mutations are predicted and are used to infer their likely inactivation mechanisms. Overall, 47.0% non-PRO/GLY mutants are stable (DeltaDeltaG < 1.0 kT) and 36.3% mutants are unstable (DeltaDeltaG > 3.0 kT),...

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PMID: 19558684
DOI: 10.1186/1757-5036-2-5

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