The molecular mechanism of temperature-dependent p53C phase separation accelerated by oncogenic mutations: insights from all-atom and coarse-grained molecular dynamics simulations.

Abstract excerpt

The aggregation of mutant p53 generally contributes to loss-of-function and gain-of-function effects, which increase cancer aggressiveness and progression. Recent studies have revealed that the DNA-binding domain of p53 (p53C) undergoes liquid-liquid phase separation (LLPS) in a temperature-dependent manner during the aggregation process. Two hotspot mutants, M237I and R249S, have been shown to accelerate this...

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