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Article

Cancer-related Mutations with Local or Long-range Effects on an Allosteric Loop of p53.

Journal of molecular biology - 15 Sept 2022

Degn Kristine, Beltrame Ludovica, Dahl Hede Freja, Sora Valentina, Nicolaci Vincenzo, Vabistsevits Marina, Schmiegelow Kjeld, Wadt Karin, Tiberti Matteo, Lambrughi Matteo, Papaleo Elena

Abstract excerpt

The tumor protein 53 (p53) is involved in transcription-dependent and independent processes. Several p53 variants related to cancer have been found to impact protein stability. Other variants, on the contrary, might have little impact on structural stability and have local or long-range effects on the p53 interactome. Our group previously identified a loop in the DNA binding domain (DBD) of p53 (residues 207-213)...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 35659507
DOI: 10.1016/j.jmb.2022.167663

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 1 Sept 2026.

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