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Article

Variable Mutations at the p53-R273 Oncogenic Hotspot Position Leads to Altered Properties.

Biophysical journal - 4 Feb 2020

Garg Ankush, Hazra Jagadish Prasad, Sannigrahi Malay Kumar, Rakshit Sabyasachi, Sinha Sharmistha

Abstract excerpt

Mutations in p53 protein, especially in the DNA-binding domain, is one of the major hallmarks of cancer. The R273 position is a DNA-contact position and has several oncogenic variants. Surprisingly, cancer patients carrying different mutant variants of R273 in p53 have different survival rates, indicating that the DNA-contact inhibition may not be the sole reason for reduced survival with R273 variants. Here, we...

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Identifiers

PMID: 31952808
DOI: 10.1016/j.bpj.2019.12.015
PMCID: PMC7002923

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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