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Article

Common cancer mutations R175H and R273H drive the p53 DNA-binding domain towards aggregation-prone conformations.

Physical chemistry chemical physics : PCCP - 7 May 2020

Li Le, Li Xuhua, Tang Yiming, Lao Zenghui, Lei Jiangtao, Wei Guanghong

Abstract excerpt

The p53 protein is a tumor suppressor and the most often mutated protein in human cancers. Recent studies reported that p53 mutants, including two of the common cancer mutants (R175H and R273H), are more prone to aggregation than wild type (WT) p53 and their pathological aggregation can lead to diverse cancers. However, the underlying molecular mechanism is poorly understood. Herein, we investigated the...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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PMID: 32307496
DOI: 10.1039/c9cp06671c

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