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Article

Complete Models of p53 Better Inform the Impact of Hotspot Mutations.

International journal of molecular sciences - 3 Dec 2022

Solares Maria J, Kelly Deborah F

Abstract excerpt

Mutations in tumor suppressor genes often lead to cancerous phenotypes. Current treatments leverage signaling pathways that are often compromised by disease-derived deficiencies in tumor suppressors. P53 falls into this category as genetic mutations lead to physical changes in the protein that impact multiple cellular pathways. Here, we show the first complete structural models of mutated p53 to reveal how...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 36499604
DOI: 10.3390/ijms232315267
PMCID: PMC9740296

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