Article

Multinucleation resets human macrophages for specialized functions at the expense of mononuclear phagocyte identity

2022-08-23

Abstract excerpt

Macrophages undergo plasma membrane fusion and cell multinucleation to form multinucleated giant cells (MGCs) such as osteoclasts in bone, Langhans giant cells (LGCs) as part of granulomas or foreign-body giant cells (FBGCs) in reaction to exogenous material. While osteoclast multinucleation is a prerequisite for vertebrate bone homeostasis, the effector function resulting from LGC and FBGC multinucleation is less...

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Literature Corpus work: 3655998c-392d-52c9-aaca-8665ebfbdc6a
DOI: 10.1101/2022.08.22.504763

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