Article

Frizzled-7 Identifies Platinum Tolerant Ovarian Cancer Cells Susceptible to Ferroptosis

2020-05-30

Abstract excerpt

Defining traits of platinum tolerant cancer cells could expose new treatment vulnerabilities. Here, new markers associated with platinum tolerant cells and tumors were identified by using in vitro and in vivo ovarian cancer (OC) models treated repetitively with carboplatin and validated in human specimens. Platinum-tolerant cells and tumors were found to be enriched in ALDH (+) cells, formed more spheroids, and...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work: c4b495c4-31da-5db5-b902-1e1147c6dd15
DOI: 10.1101/2020.05.28.121590

Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest

Frizzled-7 Identifies Platinum Tolerant Ovarian Cancer Cells Susceptible to FerroptosisDOI 10.1101/2020.05.28.121590Read

New markers for human ovarian cancer that link platinum resistance to the cancer stem cell phenotype and define new therapeutic combinations and diagnostic toolsSemantic proximity Read

Integrin-linked kinase-frizzled 7 interaction maintains cancer stem cells to drive platinum resistance in ovarian cancerSemantic proximity Read

Modeling platinum resistance in a stem-like patient-derived ovarian cancer sampleSemantic proximity Read

Integrin-linked kinase-frizzled 7 interaction maintains cancer stem cells to drive platinum resistance in ovarian cancerSemantic proximity Read

Cell-intrinsic platinum response and associated genetic and gene expression signatures in ovarian cancer cell lines and isogenic modelsSemantic proximity Read

A TAZ–ANGPTL4–NOX2 Axis Regulates Ferroptotic Cell Death and Chemoresistance in Epithelial Ovarian CancerSemantic proximity Read

Confluence analysis of multiple omics on platinum resistance of ovarian cancer.Semantic proximity Read

Cisplatin Resistant Spheroids Model Clinically Relevant Survival Mechanisms in Ovarian TumorsSemantic proximity Read

Colorectal cancer organoid models uncover oxaliplatin-resistant mechanisms at single cell resolutionSemantic proximity Read

Platinum-Induced Mitochondrial OXPHOS Contributes to Cancer Stem Cell Enrichment in Ovarian CancerSemantic proximity Read

Cell-intrinsic platinum response and associated genetic and gene expression signatures in ovarian cancerSemantic proximity Read

Wnt/β-catenin inhibition disrupts drug-tolerance in isogenic carboplatin-resistant models of Triple-Negative Breast CancerSemantic proximity Read